Glavni žreb
7. jun 2021.
| Novak Đokovic - Lorenzo Musetti | 6 (7):7 (9), 6 (2):7 (7), 6:1, 6:0, 4:0 Musetti predaje |
| Ons Jabeur - Coco Gauff | 3:6, 1:6 |
| Matteo Berrettini - Roger Federer | Federer predaje |
| Sloane Stephens - Barbora Krejcikova | 2:6, 0:6 |
| Rafael Nadal - Jannik Sinner | 7:5, 6:3, 6:0 |
| Sofia Kenin - Maria Sakkari | 1:6, 3:6 |
| Diego Schwartzman - Jan-Lennard Struff | 7 (11):6 (9), 6:4, 7:5 |
| Marta Kostyuk - Iga Swiatek | 3:6, 4:6 |
