Glavni žreb
6. septembar 2020.
| Matteo Berrettini - Casper Ruud | 6:4, 6:4, 6:2 |
| Madison Keys - Alize Cornet | 6 (4):7 (7), 2:3 Keys predaje |
| Donna Vekic - Tsvetana Pironkova | 4:6, 1:6 |
| Salvatore Caruso - Andrey Rublev | 0:6, 4:6, 0:6 |
| Maria Sakkari - Amanda Anisimova | 6:3, 6:1 |
| Marton Fucsovics - Frances Tiafoe | 2:6, 3:6, 2:6 |
| Sloane Stephens - Serena Williams | 6:2, 2:6, 2:6 |
| J.J. Wolf - Daniil Medvedev | 3:6, 3:6, 2:6 |
| Victoria Azarenka - Iga Swiatek | 6:4, 6:2 |
| Roberto Bautista Agut - Vasek Pospisil | 5:7, 6:2, 6:4, 3:6, 2:6 |
| Karolina Muchova - Sorana Cirstea | 6:3, 2:6, 7 (9):6 (7) |
| Alex DeMinaur - Karen Khachanov | 6:4, 0:6, 4:6, 6:3, 6:1 |
| Elise Mertens - Catherine Mcnally | 7:5, 6:1 |
| Felix Auger-Aliassime - Corentin Moutet | 6:1, 6:0, 6:4 |
| Marin Čilić - Dominic Thiem | 2:6, 2:6, 6:3, 3:6 |
| Ons Jabeur - Sofia Kenin | 6 (4):7 (7), 3:6 |
| Novak Đoković - Pablo Carreno Busta | 5:6 Đoković predaje |
| Jennifer Brady - Angelique Kerber | 6:1, 6:4 |
| Yulia Putintseva - Petra Martić | 6:2, 2:6, 6:4 |
| Alejandro Davidovich Fokina - Alexander Zverev | 2:6, 2:6, 1:6 |
