Glavni žreb
29. maj 2022.
| Novak Đoković - Diego Schwartzman | 6:1, 6:3, 6:3 |
| Felix Auger-Aliassime - Rafael Nadal | 6:3, 3:6, 2:6, 6:3, 3:6 |
| Alexander Zverev - Bernabe Zapata Miralles | 7 (13):6 (11), 7:5, 6:3 |
| Martina Trevisan - Aliaksandra Sasnovich | 7 (12):6 (10), 7:5 |
| Leylah Fernandez - Amanda Anisimova | 6:3, 4:6, 6:3 |
| Elise Mertens - Coco Gauff | 4:6, 0:6 |
| Jil Teichmann - Sloane Stephens | 2:6, 0:6 |
